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A selection of published research papers referencing the use of Soft X-ray Tomography
2023
Hydroxyapatite nanoparticles-cell interaction: New approaches to disclose the fate of membrane-bound and internalised nanoparticles
Mar Bonany, Ana Joaquina Perez-Berna, Eva Pereiro, Maria-Pau-Ginebra, et.al
2022
Auto-segmentation and time-dependent systematic analysis of mesoscale cellular structure in β-cells during insulin secretion
Angdi Li, Valentina Loconte, Jitin Singla. et.al.
Cryo soft X-ray tomography to explore Escherichia coli nucleoid remodelling by Hfq master regulator
Antoine Cossa, Eva Pereiro, et.al ALBA Synchroton
Contour, a semi-automated segmentation and quantitation tool for cryo-soft-X-ray tomography
Kamal L Nahas, João Ferreira Fernandes, Colin Crump, Stephen Graham, Maria Harkiolaki
A protocol for full-rotation soft X-ray tomography of single cells
Jian-Hua Chen, Axel Ekman, Ralf Bartenschlager, Venera Weinhardt, et.al
Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes
Hsin-Fang Chang, Maria Harkiolaki, et.al
The use of soft X-ray tomography to explore mitochondrial structure and function
Valentina Loconte, Kate L.White, et.al
A guide into the world of high-resolution 3D imaging: the case of soft X-ray tomography for the life sciences
Chidinma Adanna Okolo, Diamond Light Source
Soft X-ray tomograms provide a structural basis for whole-cell modeling
Valentina Loconte, Jian-Hua Chen, Bieke Vanslembrouck, Axel A. Ekman, Gerry McDermott, Mark A. Le Gros, Carolyn A. Larabell
Soft X-ray Tomography Reveals HSV-1-Induced Remodeling of Human B Cells
Jian-Hua Chen, Bieke Vanslembrouck , Axel Ekman, Vesa Aho, Carolyn A. Larabell, Mark A. Le Gros, Maija Vihinen-Ranta, Venera Weinhardt
An intensity-based post-processing tool for 3D instance segmentation of organelles in soft X-ray tomograms
Angdi Li, Valentina Loconte, Axel Ekman, Kate White, Raymond C.Stevens, et al
Microscopic Visualization of Cell-Cell Adhesion Complexes at Micro and Nanoscale
Bieke Vanslembrouck, Jian-hua Chen, Carolyn Larabell, Jolanda van Hengel
Advanced Light Source Analytical Techniques for Exploring the Biological Behavior and Fate of Nanomedicines
Mingjing Cao, Kai Zhang, Shuhan Zhang, Yaling Wang, and Chunying Chen
Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection
Kamal L.Nahas, Maria Harkiolaki, Colin M. Crump et.al
Correlative imaging using super-resolution fluorescence microscopy and soft X-ray tomography at cryogenic temperatures provides a new way to assess virosome solutions for vaccine development
Chidinma A.Okolo, Maria Harkiolaki.et.al
A combination of soft X-ray and laser light sources offer 3D high content information on the native state of the cellular environment
Chidinma A Okolo, Thomas M Fish, Kamal L Nahas, Archana C Jadhav, Nina Vyas, Adam Taylor and Maria Harkiolaki
2021
Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy
Zheng Dang, et al, Hefei Soft-X-ray Beamline, China
Probing the Intracellular Bio-Nano Interface in Different Cell Lines with Gold Nanostars
Cecilia Spedalieri, et al, Department of Chemistry, Humboldt-Universität, Department X-ray Microscopy, Helmholtz-Zentrum, Berlin
Influence of Nuclear Localization Sequences on the Intracellular Fate of Gold Nanoparticles
Daniela Drescher, et al, Department of Chemistry, Humboldt-Universität, Department of X-Ray Microscopy, Helmholtz-Zen trum, Berlin
Correlative cryo-imaging of the cellular universe with soft X-rays and laser light used to track F-actin structures in mammalian cells
Mohamed Koronfel, et al, Diamond Light Source, Institute of Molecular and Cell Biology
Using soft X-ray tomography for rapid whole-cell quantitative imaging of SARS-CoV-2-infected cells
Valentina Loconte, Jian-Hua-Chen, et al, Lawrence Berkeley National Laboratory, USA
Imaging of Virus-Infected Cells with Soft X-ray Tomography
Damià Garriga, et al, ALBA Synchrotron Light Source, Centro Nacional de Biotecnología, Spain
Malaria Pigment Crystals, the Achilles Heel of the Malaria Parasite
Sergey Kapishnikov, Weizmann Institute of Science. ChemMedChem
SARS-CoV-2 Assembly and Egress Pathway Revealed by Correlative Multi-modal Multi-scale Cryo-imaging
Luiza Mendonca, Wellcome Trust Centre for Human Genetics, University of Oxford
3D Whole-Cell Mapping of Insulin Secretion
Carolyn Larabell, Advanced Light Source, Berkeley Lab
3D Imaging and Quantification of the Integrin at a Single-Cell Base on a Multisignal Nanoprobe and Synchrotron Radiation Soft X-ray Tomography Microscopy
Chunyu Zhang, et al, Anal.Chem, 2021
Multimodal Imaging and Soft X-Ray Tomography of Fluorescent Nanodiamonds in Cancer Cells
Philipp Reineck, et al, ARC Centre of Excellence for Nanoscale BioPhotonics. Biotechnology Journal 2021
Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells
Alice Dupont Juhl, et al, VILLUM Center for Bioanalytical Sciences, Denmark,
Cryo-Structured Illumination Microscopic Data Collection from Cryogenically Preserved Cells
Nina Vyas, et al, Harwell Science and Innovation Campus, Beamline B24, Diamond Light Source
Compact Cell Imaging Device (CoCID) provides insights into the cellular origins of viral infections
Kenneth Fahy et al 2021 J. Phys. Photonics
Single Cell Cryo-Soft X-Ray Tomography shows that each Chlamydia Trachomatis Inclusion is a unique community of bacteria
Patrick Phillips, et al, Diamond Light Source, Harwell Science and Innovation Campus, UK
2020
Quantitative three‐dimensional nondestructive imaging of whole anaerobic ammonium‐oxidizing bacteria
M-W Peng, Chongqing University, China. Journal of Synchrotron Radiation
Synchrotron multimodal imaging in a whole cell reveals lipid droplet core organization
Frederic Jamme, Synchrotron SOLEIL, France. Journal of Synchrotron Radiation
3D Correlative Cryo-Structured Illumination Fluorescence and Soft X-ray Microscopy Elucidates Reovirus Intracellular Release Pathway
Ilias Kounatidis, Diamond Light Source, UK. PubMed.gov
X‑ray tomography of cryopreserved human prostate cancer cells: mitochondrial targeting by an organoiridium photosensitiser
E. M. Bolitho, University of Warwick, UK. Journal of Biological Inorganic Chemistry
Cells Undergo Major Changes in the Quantity of Cytoplasmic Organelles after Uptake of Gold Nanoparticles with Biologically Relevant Surface Coatings
Burcu Kepsutlu, Helmholtz Zentrum Berlin für Materialien und Energie GmbH, Germany
Strong intracellular signal inactivation produces sharper and more robust signaling from cell membrane to nucleus
Jingwei Ma, Department of Mathematics and Statistics, Boston University
2019
Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo
Sergey Kapishnikov, Niels Bohr Institute, Copenhagen. PNAS
Soft X-Ray Microscopy of Complex Samples - from Tissue Culture to Tissue Components
Casper Hempel, Technical University of Denmark. Wiley Analytical Science
3D Quantitative and Ultrastructural Analysis of Mitochondria in a Model of Doxorubicin Sensitive and Resistant Human Colon Carcinoma Cells
Claudia Moscheni, Universita degli Studi di Milano. OubMed.gov
Correlative cryo-soft X-ray tomography of cells
Eva Pereiro, ALBA Synchhrotron, Barcelona. Springer Biophysical Reviews
2018
Expanding horizons of cryo-tomography to larger volumes
Michael Elbaum, ScienceDirect
Analysis of cholesterol export from endo-lysosomes by Niemann Pick C2 protein using combined fluorescence and X-ray microscopy
Alice Dupont, Villum Center for Biological Sciences, Denmark
Native-state imaging of calcifying and noncalcifying microalgae reveals similarities in their calcium storage organelles
Matthew C. Spink, Diamond Light Source, et al. Microscience & Microanalysis
Cryo-soft X-ray tomography: using soft X-rays to explore the ultrastructure of whole cells
Maria Harkiolaki, Diamond Light Source, UK. et al. Emerging Topics in Life Science
Integration of Soft X-ray Tomography and High Resolution Fluorescence Microscopy
Zi-Jing Lin, National Synchrotron Radiation Research Center, Taiwan Microscience & Microanalysis
Correlation of Cryo Soft X-ray Tomography with Cryo Fluorescence Microscopy to Characterise Cellular Organelles at Beamline B24, Diamond Light Source
Matthew C. Spink, Diamond Light Source, et al. Microscience & Microanalysis
PSF correction in soft x-ray tomography
Axel Ekmana, Venera Weinhardt, Dept of Anatomy, UCSF Journal of Structural Biology
2017
Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells
Fernando Ugarte et al, Stem Cell Reports
Biochemistry of malaria parasite infected red blood cells by X-ray microscopy
S. Kapishnikov et al, Nature
3D membrane segmentation and quantification of intact thick cells using cryo soft X-ray transmission microscopy: A pilot study
Ruben Cardenes et al, PLOS ONE
Mycobacterium tuberculosis replicates within necrotic human macrophages
Thomas L. Lerner et al, Journal of Cell Biology
Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
Tohru Takaki et al, Nature Communications
Mitosis can drive cell cannibalism through entosis
Joanne Durgan et al, eLIFE
2016
Soft X-ray Tomography Reveals Gradual Chromatin Compaction and Reorganization during Neurogenesis in Vivo.
Mark A. Le Gros et al, Cell Reports
Cryo‑soft X‑ray tomography as a quantitative three‑dimensional tool to model nanoparticle:cell interaction
Michele Chiappi et al, Journal of Nanobiotechnology
Herpes simplex virus 1 induces egress channels through marginalized host chromatin
Markko Myllys et al, Nature / Scientific Reports
Structural Changes In Cells Imaged by Soft X‑ray Cryo-Tomography During Hepatitis C Virus Infection
Ana J. Perez-Berna et al, ACS Nano
Resolving new ultrastructural features of cytokinetic abscission with soft-X-ray cryo-tomography
Shachar Sherman et al, Nature / Scientific Reports
Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography
Michele C. Darrow, Journal of Cell Science
Putting molecules in their place
Bertrand P. Cinquin, Journal of Cellular Biochemistry
Development of Correlative Cryo-soft X‑ray Tomography and Stochastic Reconstruction Microscopy. A Study of Cholesterol Crystal Early Formation in Cells
Neta Varsano, Journal of the Americal Chemical Society
Correlative cryo-fluorescence and cryo-soft X-ray tomography of adherent cells at European synchrotrons
R. Carzaniga et al, Methods in Cell Biology
2015 and Older
Analysis of ER–mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells
Kristin Elgass et al, Journal of Cell Science
The yeast polo kinase, Cdc5, regulates the shape of the mitotic nucleus
Alison D. Walters et al, Current Biology
A 3D cellular context for the macromolecular world
Ardan Patwardhan et al, Nature Structural & Molecular Biology
Quantitatively Imaging Chromosomes by Correlated Cryo-Fluorescence and Soft X-Ray Tomographies
Elizabeth A Smith et al, Biophysical Journal
Imaging endosomes and autophagosomes in whole mammalian cells using correlativecryo-fluorescenceandcryo-softX-raymicroscopy (cryo-CLXM)
Elizabeth Duke et al, Ultramicroscopy
Three-dimensional imaging of human stem cells using soft X-ray tomography
J.C. Niclis et al, Nature Methods
Imaging Drosophila brain by combining cryo-soft X-ray microscopy of thick vitreous sections and cryo-electron microscopy of ultrathin vitreous sections
Amélie Leforestier et al, Journal of Structural Biology
Visualizing Cell Architecture and Molecular Location Using Soft X-Ray Tomography and Correlated Cryo-Light Microscopy
Gerry McDermott et al, Annual Reviews of Physical Chemistry
