Keep up to date for everything Sirius XT

Correlative cryo light and soft X-ray tomography- Imaging Insights
๐๐ข๐ซ๐ข๐ฎ๐ฌ๐๐ ๐ข๐ฌ ๐ฉ๐ฅ๐๐๐ฌ๐๐ ๐ญ๐จ ๐ฌ๐ก๐๐ซ๐ ๐ฌ๐จ๐ฆ๐ ๐๐ฆ๐๐ ๐ข๐ง๐ ๐๐ง๐ฌ๐ข๐ ๐ก๐ญ๐ฌ ๐ญ๐ก๐๐ญ ๐ฆ๐๐ฒ ๐๐ ๐จ๐ ๐ข๐ง๐ญ๐๐ซ๐๐ฌ๐ญ ๐ญ๐จ ๐ฒ๐จ๐ฎ. We plan to make Imaging Insights a regular post providing

๐๐๐ฌ๐ฌ๐๐๐ก๐ฎ๐ฌ๐๐ญ๐ญ๐ฌ ๐๐ง๐ฌ๐ญ๐ข๐ญ๐ฎ๐ญ๐ ๐จ๐ ๐๐๐๐ก๐ง๐จ๐ฅ๐จ๐ ๐ฒ (๐๐๐) ๐๐จ๐จ๐ฅ ๐๐๐ฅ๐ค๐ฌ ๐ข๐ง๐ฏ๐ข๐ญ๐๐ฌ ๐๐ข๐ซ๐ข๐ฎ๐ฌ๐๐ ๐ญ๐จ ๐ฉ๐ซ๐๐ฌ๐๐ง๐ญ ๐ข๐ญ๐ฌ ๐๐๐๐ฅ๐-๐๐จ๐ฉ ๐๐จ๐๐ญ ๐-๐ซ๐๐ฒ ๐๐ข๐๐ซ๐จ๐ฌ๐๐จ๐ฉ๐
We are excited to announce that SiriusXT is coming to the Massachusetts Institute of Technology to present its table-top Soft X-ray microscope, SXT-100. Dr Kenneth

Efficient EM grid mapping using cryo soft X-ray microscopy- Imaging Insights
๐๐ข๐ซ๐ข๐ฎ๐ฌ๐๐ ๐ข๐ฌ ๐ฉ๐ฅ๐๐๐ฌ๐๐ ๐ญ๐จ ๐ฌ๐ก๐๐ซ๐ ๐ฌ๐จ๐ฆ๐ ๐๐ฆ๐๐ ๐ข๐ง๐ ๐๐ง๐ฌ๐ข๐ ๐ก๐ญ๐ฌ ๐ญ๐ก๐๐ญ ๐ฆ๐๐ฒ ๐๐ ๐จ๐ ๐ข๐ง๐ญ๐๐ซ๐๐ฌ๐ญ ๐ญ๐จ ๐ฒ๐จ๐ฎ. We plan to make Imaging Insights a regular post providing

UCD Conway imaging core welcomes a new addition to the facility- Table Top Soft X-ray microscope
Conway Imaging Core at University College Dublin (UCD) has welcomed its latest addition โ the Table Top Soft X-ray Microscope. The microscope is set to

First installation of SXT-100 Soft X-ray Microscope at Conway UCD
SiriusXT marks a significant milestone with the first deployment of the SXT100 Soft X-Ray microscope at Conway Imaging Institute, UCD, Dublin. SiriusXTโs SXT-100 is the

๐๐ข๐ซ๐ข๐ฎ๐ฌ๐๐ ๐๐๐ฅ๐๐๐ซ๐๐ญ๐๐ฌ ๐๐๐ฏ๐๐ง๐๐๐ฆ๐๐ง๐ญ๐ฌ ๐ข๐ง ๐๐ฅ๐ณ๐ก๐๐ข๐ฆ๐๐ซ’๐ฌ ๐๐๐ฌ๐๐๐ซ๐๐ก โ ๐๐จ๐ ๐๐ญ๐ก๐๐ซ, ๐๐จ๐ฐ๐๐ซ๐๐ฌ ๐ ๐๐ฎ๐ซ๐
On this World Alzheimer’s Day (21st September 2023), we would like to reflect on the advancements achieved in understanding Alzheimer’s disease, as well as the

SiriusXT advocating for Mitochondrial Health during World Mitochondrial Disease Week! ๐
Mitochondrial disease, though once considered rare, now affects approximately 1 in 5,000 individuals, positioning it as the second most frequently diagnosed serious genetic ailment after

SiriusXT partnered Pan European Biomedical Imaging Research Project Secures โฌ2.5 million in Funding
A new University College Dublin (UCD) led pan-European research project using correlative multimodal imaging (CMI) to improve the understanding of biomedical processes of disease and

SiriusXT to attend and exhibit at two leading microscopy conferences in July 2023
SiriusXT, a pioneer in Laboratory Soft X-ray Microscopy, is proud to announce its plans to participate in two leading microscopy conferences in July 2023. These

Seeing the Big Picture with Wide-Angle Correlative Light and X-ray Microscopy (CLXM)
SiriusXTโs SXT-100 Soft X-ray Microscope images with a wide field-of-view that offers a unique means of imaging inter- and intracellular structure of closely packed cells,

Increasing cancer death rates and 5-year survival rates suggest improvements in therapeutics and care but not in cures and vaccines โ more cancer research needed!
Daffodil Day is an annual fundraising event held in many countries to raise awareness and funds for cancer research and support services. The day typically

New research paper highlights benefits of integrating Fluorescence and Soft X-ray Microscopy
Soft X-ray tomography (SXT) is a powerful microscopy technique for studying three-dimensional (3D) structures in biological and materials research. Off-line fluorescence microscopy (FM) is often

๐๐ข๐ ๐ก-๐๐ก๐ซ๐จ๐ฎ๐ ๐ก๐ฉ๐ฎ๐ญ ๐๐จ๐๐ญ ๐-๐ซ๐๐ฒ ๐๐จ๐ฆ๐จ๐ ๐ซ๐๐ฆ ๐๐๐ช๐ฎ๐ข๐ฌ๐ข๐ญ๐ข๐จ๐ง ๐๐ง๐ ๐๐๐๐จ๐ง๐ฌ๐ญ๐ซ๐ฎ๐๐ญ๐ข๐จ๐ง- using the SXT-100 Table-Top Soft X-ray Microscope and employing fully automated fiducial-less alignment of tomographic tilt series
Imaging the whole internal structure of intact biological cells at nanometre-resolution, by first acquiring a +/- 65 degree tilt series with one-degree tilt increments and

SiriusXT presents at Euro-BioImaging Virtual Pub, Tech Exchange 2023
On 27th January 2023, Kenneth Fahy (VP of Product Management, SiriusXT) spoke in the latest episode of the Euro-BioImaging Tech Exchange webinar series. This was

Celebrating World Cancer Day 2023 showcasing role of Soft X-ray Tomography in Cancer research
World Cancer Day is observed worldwide on February 4. The aim is to inform and encourage people on its prevention, early detection, and treatment. Cancer

Cryo SXT gives new approaches to investigating intracellular calcium of cells with internalised nanoparticles.
Hydroxyapatite (HA) in the form of nanoparticles (NPs) is widely used as a vehicle for the transport of genetic material into cells and in bone

Advances in table-top soft X-ray sources are predicted to rapidly expand the application of Soft X-ray Tomography for whole-cell modelling
As we approach the end of 2022, the soft X-ray microscopy community can look back on a year of continued growth in the use of

Use of soft X-ray tomography in interaction of Au NPs with bacterial cells
Gold nanoparticles have important diagnostic and therapeutic uses. Furthermore, they have recently been found to act as potent antimicrobial agents. Soft X-ray tomography (SXT) was

Celebrating World Diabetes Day 2022- 14 November
The global diabetes prevalence in 20 to 79 year olds in 2021 was estimated at over 530 million people, giving rise to healthcare costs of

National Herpes Day- 13 October 2022
National Herpes Awareness Day, celebrated on October 13, is a chance to promote awareness about the causes, dangers, and treatment of many forms of herpes

Soft X-ray Microscopy at M&M2022 Conference in Portland – promoting 3D imaging of intact biological cells in their native state
It was great to see the premier microscopy event of 2022 taking place again as an in-person event at the beautiful Oregon Convention Center in

Cryo soft X-ray tomography of whole cells and bulk tissue samples in the laboratory
Cryo soft X-ray tomography using low-energy X-rays is a powerful method for imaging the 3D ultrastructure of whole cells to around 50 nm resolution. Cells

Correlating soft X-ray tomography with super-resolution fluorescence microscopy brings a new method of evaluating virosome solutions for vaccine development
Virosomes, which are like non-replicating “artificial viruses,” are capable of delivering vaccination antigens to targeted sites in a host cell. In general, a virosome is

World Sickle Cell Day 2022
The 19th of June has been designated as World Sickle Cell Awareness Day, the purpose of which is to enhance public education and understanding of

Structural analysis of Glioblastoma Multiforme Brain Tumour cells, using Soft X-ray Microscopy, help researchers to link DNA damage with cell structure changes
Glioblastoma multiforme (GBM) is a fast-growing glioma brain tumour arising from brain cells, called glial cells, and is the most common type of primary malignant

Contour, a new semi-automated segmentation and quantitation tool for Cryo soft X-ray tomography
Cryo-soft X-ray tomography (cryo-SXT) is an emerging imaging technology that solves the demand for imaging the whole ultrastructure of relatively thick cell samples without staining

Soft X-ray Tomography can image cell-cell adhesion complexes at nanometer resolution providing 3D structural information that helps reveal the remaining secrets of these complex intercellular structures.
Cell adhesion is the process by which cells interact with and connect to neighbouring cells via specialized cell surface chemicals. This process can take place

Two Days CoCID meeting held at ALBA Synchrotron, Spain
On May 9th and 10th members of the CoCID consortium convened at the Alba synchrotron for the second, in-person, CoCID meeting. Twenty participants with representatives

World Asthma Day May 3 2022
World Asthma Day is an annual event hosted by the Global Initiative for Asthma to raise asthma awareness and care across the world. The theme

World Malaria Day April 25 2022
World Malaria Day is an annual event observed on April 25 to promote awareness of the global effort to control and eventually eradicate malaria. According

World Liver Day
Every year on April 19, World Liver Day is celebrated with the goal of raising liver health awareness and also of drawing attention to liver

Soft X-ray Tomography could help detect the onset of Multiple Sclerosis
A recently-reported study, conducted by researchers from the Harvard T.H. Chan School of Public Health and published in the US National Institute of Healthโs Research

The case for Soft X-ray Tomography in the Bioimaging World
The most appropriate cell imaging modality for a given bioimaging application is a trade-off between the deliverables associated with the optical setup of the microscope

Soft X-ray Tomography (SXT) helps correlate disease and drug therapy mechanisms with changes in cellular structure
Soft x-ray tomography is an ideal imaging modality for characterizing organelle assembly within a biological cell, which informs the disease researcher about cellular mechanisms in

Daffodil Day helps highlight the need for ongoing cancer research
Daffodil Day is an annual campaign that raises life-saving funds for world-class cancer research. It helps highlight the immense pain and economic cost that cancer

Getting the big picture!
Soft X-ray Tomography (SXT) is an ideal imaging modality for mapping the interaction of organelle within biological cells, given its ability to image the whole

A paper describing a step-by-step sample preparation, data collection and cell segmentation protocol for full-rotation Soft X-ray Tomography (SXT)
This paper from the Advanced Light Source, LBNL, presents a detailed step by step protocol for full rotation soft X-ray tomography (SXT) of single cells.

Soft X-ray Tomography (SXT) โ a means to explore mitochondrial structure and function
Mitochondria are membrane-bound cell organelles that generate most of the chemical energy needed to power the cell’s biochemical reactions. Mitochondria form a dynamic and interconnected

Cryo-SXT helps researchers understand how the Hepatitis-C virus changes a cellโs structure and shows how antiviral drugs can reverse these changes
Hepatitis C virus (HCV) is an enveloped RNA virus. One of the hallmarks of HCV infection is a rearrangement of the host cell membranes, known

Soft X-ray Tomography helps demonstrate the benefits of using nanoparticles in drug delivery
Nanoparticles are increasingly being used to improve the bioavailability of a range of drugs, vaccines, adjuvants etc. to targeted sites within a cell. Targeting a

A growing role for Soft X-ray Microscopy in Nanomedicine Research
2021 saw a significant increase in nanomedicine research and, in particular, in the use of nanoparticles as transport carriers for the precise delivery of vaccines,

Imaging actin filaments in a cell / Finding needles in a Christmas tree
The paper below does a great job of elucidating the benefits of correlating soft x-ray tomography with super-resolution fluorescence microscopy in order to image the

SXT imaging has the ability to investigate the potential of SARS-CoV-2 virions.
The analysis of 3D architecture of infected cells is critical for understanding the mechanisms of viral diseases. Soft X-ray tomography (SXT) is a technology that

Soft X-ray Tomography Imaging of Virus-infected Cells
Viruses are obligate parasites that depend on a host cell for replication and survival. Consequently, to fully understand the viral processes involved in infection and

Two Days CoCid Team Meeting held in Dublin, Ireland
Monday, October 27th, 2021, was the day that many of the CoCID team members had been looking forward to. The day when team members from

Celebrating 100 Years of Insulin as a Diabetes Therapy – while using soft x-ray microscopy to develop a diabetes cure
2021 marks the 100-year anniversary of the discovery of Insulin as a treatment for Diabetes. In 1921, Sir Frederick G Banting and Charles H Best,

โThe future of bioimaging is in the crosstalk between different imaging modalitiesโ
โ The challenge in understanding the complex spatial systems of entire organs and tumours will only be met by designing new multimodal and correlative workflows

Soft X-Ray microscopy shows how viral pathogens penetrate human cells
”The SXM microscope developed by SiriusXT performs just as well but is many times smaller, less expensive, and still very fast.” – Dr Venera Weinhardt,

SiriusXT presents at The European Light Microscopy Initiative 2021 (elmi 2021)
The European Light Microscopy Initiative 2021 (elmi2021) conference took place virtually this year, between June 22ndย and 25th. SiriusXT was pleased with the interest received in

Compact Cell Imaging Device (CoCID) provides insights into the cellular origins of viral infections
”Viral diseases are not only an important cause of mortality, they also carry a significant social and economic cost to humanity. ย An analysis of three-dimensional