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Publications

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2025
Canine parvovirus infection affects host cell nucleolar organization and ribosome biogenesis

Moona Huttunen, Satu Hakanen, Vesa Aho, Simon Leclerc, Aynur Soenmez, Sergey Kapishnikov, Alessandro Zannotti, Visa Ruokolainen, Kari Salokas, Markku Varjosalo, Leena Latonen, Colin R. Parrish, Kenneth Fahy, Salla Mattola, Denis L. J. Lafontaine & Maija Vihinen-Ranta

Soft X-ray tomography analysis of mitochondria dynamics in Saccharomyces cerevisiae

Wei-Ling Huang, Chang-Lin Chen, Zi-Jing Lin, Chia-Chun Hsieh, Mo Da-Sang Hua, Chih-Chan Cheng, Tzu-Hao Cheng, Lee-Jene Lai & Chuang-Rung Chang

Three dimensional visualization of subcellular and suborganellar structures in near-native plant cells by synchrotron soft X-ray tomography

Mo Da-Sang Hua, Yi-Hung Lin, Chia-Chun Hsieh, Chang-Lin Chen, Zi-Jing Lin
Soft X-ray tomography reveals variations in B. subtilis biofilm structure upon tasA deletion

Anthoula Chatzimpinou, Anne Diehl, A Tobias Harhoff, Kristina Driller, Bieke Vanslembrouck, Jian-Hua Chen, Kristaps Kairišs, Valentina Loconte, Mark A Le Gros, Carolyn Larabell, Kürşad Turgay, Hartmut Oschkinat, Venera Weinhardt
Demonstrating soft X-ray tomography in the lab for correlative cryogenic biological imaging using X-rays and light microscopy

Stephen O’Connor, David Rogers, Maryna Kobylynska, James A. Geraets, Katja Thaysen, Jacob Marcus Egebjerg, Madeleen C. Brink, Louisa Herbsleb, Michaela Salakova, Leon Fuchs, Frauke Alves, Claus Feldmann, Axel Ekman, Paul Sheridan, William Fyans, Tony McEnroe, Fergal O’Reilly, Kenneth Fahy, Roland A. Fleck, Daniel Wüstner, Jeremy C. Simpson, Andreas Walter & Sergey Kapishnikov

Automated segmentation of soft X-ray tomography: Native cellular structure with submicron resolution at high-throughput for whole-cell quantitative imaging in yeast

Jianhua Chen, Mary Mirvis, Axel Ekman, Bieke Vanslembrouck, Mark Le Gros, Carolyn Larabell, and Wallace F. Marshall
Rapid hepatitis C virus replication machinery removal after antiviral treatment with DAA monitored by multimodal imaging

Victoria Castro1, Gema Calvo1, Ana J. Pérez-Berná2, Kevin Mamprin2, Sergey Kapishnikov3, David Rogers, Stephen O’Connor, Paul Sheridan, Kenneth Fahy, Eva Pereiro, Pablo Gastaminza
Bridging the resolution gap in cryo-CLEM by introducing cryo-SXT: cryo-CLXEM

Johannes Groen, Anastasia Gazi, Sergey Kapishnikov, Anne Brelot, Matthijn Vos, Jost Enninga, Eva Pereiro, Anna Sartori-Rupp
Robust Deep Denoising of Soft X-Ray Tomography Data for Biological Research: Targeting Tilt Series Versus Reconstructed Tomograms

ShaoSen Chueh, Jeremy C. Simpson, Sergey Kapishnikov
Rapid hepatitis C virus replication machinery removal after antiviral treatment with DAA monitored by multimodal imaging

Victoria Castro, Gema Calvo, Ana J. Pérez-Berná, Kevin Mamprin, Sergey Kapishnikov, David Rogers, Stephen O’Connor, Paul Sheridan, Kenneth Fahy, Eva Pereiro, Pablo Gastaminza
Soft X-Ray Tomography Has Evolved into a Powerful Tool for Revealing Cell Structures

Venera Weinhardt, Carolyn Larabell
SXTractor: A Self-Supervised Feature Extractor of Soft X-Ray Images That Enables Few-Shot Tomogram Segmentation

ShaoSen Chueh, Madeleen C. Brink, Jeremy C. Simpson, Sergey Kapishnikov
Soft X-ray tomography reveals variations in B. subtilis biofilm structure upon tasA deletion

Anthoula Chatzimpinou, Anne Diehl, A. Tobias Harhoff, Kristina Driller, Bieke Vanslembrouck, Jian-Hua Chen, Kristaps Kairišs, Valentina Loconte, Mark A. Le Gros, Carolyn Larabell, Kürşad Turgay, Hartmut Oschkinat & Venera Weinhardt
2024
Automated segmentation of soft X-ray tomography: native cellular structure with sub-micron resolution at high throughput for whole-cell quantitative imaging in yeast

Jianhua Chen, Mary Mirvis, Axel Ekman, Bieke Vanslembrouck, Mark Le Gros, Carolyn Larabell, Wallace F. Marshall
Unraveling Actin Dynamics in Toxoplasma gondii Using Soft X-ray Tomography for 3D Cellular Imaging

Christina L. Hueschen, Li-av Segev-Zarko, Jian-Hua Chen, Mark A. LeGros, Carolyn A. Larabell, John C. Boothroyd, Rob Phillips & Alexander R. Dunn
Subcellular Feature-Based Classification of α and β Cells Using Soft X-ray Tomography

Aneesh Deshmukh, Kevin Chang, Janielle Cuala, Bieke Vanslembrouck, Senta Georgia, Valentina Loconte, Kate L. White.
Automated 3D CytoplasmSegmentation in Soft X-Ray Tomography

Ayse Erozan, Philipp D. Lösel, Vincent Heuveline, Venera Weinhardt
Soft X-ray tomography reveals variations in B.subtilis biofilm structure upon tasA deletion

Anthoula Chatzimpinou, Anne Diehl, A. Tobias Harhoff, Kristina Driller, Bieke Vanslembrouck, Jian-Hua Chen, Kristaps Kairiss, Valentina Loconte, Mark A Le Gros, Carolyn Larabell, Kürşad Turgay, Hartmut Oschkinat, Venera Weinhardt
Laboratory based correlative cryo-soft X-ray tomography and cryo-fluorescence microscopy

Kenneth Fahy, Sergey Kapishnikov, Martina Donnellan, Tony McEnroe, Fergal O’Reilly, William Fyans, Paul Sheridan
Hydrophilicity Affects Stress Response of COS-7 Fibroblast-Like Cells Exposed to Functionalised Gold Nanoclusters

Denver Linklater, Xavier Le Guével, Erim Kosyer, Sergey Rubanov, Gary Bryant, Vladimir Baulin, Eva Pereiro, Palalle G.Tharushi Perera, Jason Wandiyanto, Ana Angulo, et al.
Applying 3D correlative structured illumination microscopy and X-ray tomography to characterise herpes simplex virus-1 morphogenesis

Kamal L. Nahas, Viv Connor, Kaveesha J. Wijesinghe,, Henry G. Barrow, Ian M. Dobbie, Maria Harkiolaki, Stephen C. Graham, Colin M. Crump
Investigating beta cell structural heterogeneity using soft X-ray tomography

Kevin S. Chang, Aneesh Deshmukh, Kate L. White, Valentina Loconte
Cryogenic Soft X-ray Tomography helps reveal how protein blockingpores in cells, can lead to attenuated inflammation

Chidinma Adanna Okolo, Jack Jonathan Maran, Amy Watts, Jamie Maripillan, Maria Harkiolaki, Agustín D. Martínez, Colin R. Green , Odunayo Omolola Mugisho.
Correlative cryo-soft X-ray tomography and cryo-structured illumination microscopy reveal changes to lysosomes in amyloid-β-treated neurons

Karen E.Marshall, Kurtis Mengham, Matthew C.Spink, Lyra Vania, Hannah Jane Pollard, Michele C.Darrow, Elizabeth Duke, Maria Harkiolaki, Louise C.Serpell
Near-Native Imaging of Label-Free Silver Nanoparticles-Triggered 3D Subcellular Ultrastructural Reorganization in Microalgae

Shuai Xu, Xia-Yu Tao, Zheng Dang, YuTing Wang, Yong Guan, Zhao Wu, Gang Liu, YangChao Tian, and Li-Jiao Tian
2023
Hydroxyapatite nanoparticles-cell interaction: New approaches to disclose the fate of membrane-bound and internalised nanoparticles

Mar Bonany, Ana Joaquina Perez-Berna, Eva Pereiro, Maria-Pau-Ginebra, et.al
On-Line Fluorescence Microscopy for Identification and Imaging of Apoptotic Cell with Synchrotron-Based Soft X-ray Tomography

Chao Zhang, Zhao Wu, Zheng Dang, Lijiao Tian, Yong Guan, Gang Liu and Yangchao Tian
Extending Imaging Volume in Soft X-Ray Tomography

Axel Ekman, Jian-Hua Chen, Bieke Vanslembrouck, Valentina Loconte,
Carolyn A. Larabell, Mark A. Le Gros, and Venera Weinhardt
Direct Visualization and Restoration of Metallic Ion-Induced Subcellular Ultrastructural Remodeling

Zheng Dang, Xia-Yu Tao, Yong Guan, Zhao Wu, Ying Xiong, Gang Liu, YangChao Tian,*
and Li-Jiao Tian
Shedding Light on Osteosarcoma Cell Differentiation: Impact on Biomineralization and Mitochondria Morphology

Francesca Rossi, Andrea Sorrentino, Eva Pereiro, et.al
3D surface reconstruction of cellular cryo- soft X- ray microscopy tomograms using semisupervised deep learning

Michael C. A. Dyhr, Stephan Werner, Gerd Schneider, James McNally, et.al
Dehydration as alternative sample preparation for soft X‐ray tomography

Anthoula Chatzimpinou, Charlotta Funaya, David Rogers, Stephen O’Connor, Sergey Kapishnikov, Paul Sheridan, Kenneth Fahy, Venera Weinhardt
Three-Dimensional Remodeling of SARS-CoV2-InfectedCells Revealed by Cryogenic Soft X‑ray Tomography

Victoria Castro, Ana Joaquina Pérez-Berna, Gema Calvo, Eva Pereiro and Pablo Gastaminza
Chaperonin CCT controls extracellular vesicle production and cell metabolism through kinesin dynamics

Amelia Rojas-Gómez, Sara G. Dosil, Joaquin Otón,, Andrea Sorrentino, Eva Pereiro, Francisco Sánchez-Madrid, Noa B. Martín-Cófreces, et.al
Functionalized Gold Nanoclusters Promote Stress Response in COS-7 Cells

Denver P. Linklater, Xavier Le Guével, Erim Kosyer, Gary Bryant, Eric Hanssen, Vladimir A. Baulin, Eva Pereiro, Palalle G.Tharushi Perera, Jason V. Wandiyanto, Ana Angulo, Saulius Juodkazis, Elena P. Ivanova, et.al
Hydroxyapatite nanoparticles-cell interaction: New approaches to disclose the fate of membrane-bound and internalised nanoparticles

Mar Bonany, Ana Joaquina Perez-Berna, Eva Pereiro, Maria-Pau-Ginebra, et.al
On-Line Fluorescence Microscopy for Identification and Imaging of Apoptotic Cell with Synchrotron-Based Soft X-ray Tomography

Chao Zhang, Zhao Wu, Zheng Dang, Lijiao Tian, Yong Guan, Gang Liu and Yangchao Tian
Extending Imaging Volume in Soft X-Ray Tomography

Axel Ekman, Jian-Hua Chen, Bieke Vanslembrouck, Valentina Loconte,
Carolyn A. Larabell, Mark A. Le Gros, and Venera Weinhardt
Direct Visualization and Restoration of Metallic Ion-Induced Subcellular Ultrastructural Remodeling

Zheng Dang, Xia-Yu Tao, Yong Guan, Zhao Wu, Ying Xiong, Gang Liu, YangChao Tian,*
and Li-Jiao Tian
Shedding Light on Osteosarcoma Cell Differentiation: Impact on Biomineralization and Mitochondria Morphology

Francesca Rossi, Andrea Sorrentino, Eva Pereiro, et.al
3D surface reconstruction of cellular cryo- soft X- ray microscopy tomograms using semisupervised deep learning

Michael C. A. Dyhr, Stephan Werner, Gerd Schneider, James McNally, et.al
Dehydration as alternative sample preparation for soft X‐ray tomography

Anthoula Chatzimpinou, Charlotta Funaya, David Rogers, Stephen O’Connor, Sergey Kapishnikov, Paul Sheridan, Kenneth Fahy, Venera Weinhardt
Three-Dimensional Remodeling of SARS-CoV2-InfectedCells Revealed by Cryogenic Soft X‑ray Tomography

Victoria Castro, Ana Joaquina Pérez-Berna, Gema Calvo, Eva Pereiro and Pablo Gastaminza
Chaperonin CCT controls extracellular vesicle production and cell metabolism through kinesin dynamics

Amelia Rojas-Gómez, Sara G. Dosil, Joaquin Otón,, Andrea Sorrentino, Eva Pereiro, Francisco Sánchez-Madrid, Noa B. Martín-Cófreces, et.al
Functionalized Gold Nanoclusters Promote Stress Response in COS-7 Cells

Denver P. Linklater, Xavier Le Guével, Erim Kosyer, Gary Bryant, Eric Hanssen, Vladimir A. Baulin, Eva Pereiro, Palalle G.Tharushi Perera, Jason V. Wandiyanto, Ana Angulo, Saulius Juodkazis, Elena P. Ivanova, et.al
2022
Auto-segmentation and time-dependent systematic analysis of mesoscale cellular structure in β-cells during insulin secretion

Angdi Li, Valentina Loconte, Jitin Singla. et.al.
Cryo soft X-ray tomography to explore Escherichia coli nucleoid remodelling by Hfq master regulator

Antoine Cossa, Eva Pereiro, et.al ALBA Synchroton
Contour, a semi-automated segmentation and quantitation tool for cryo-soft-X-ray tomography

Kamal L Nahas, João Ferreira Fernandes, Colin Crump, Stephen Graham, Maria Harkiolaki
A protocol for full-rotation soft X-ray tomography of single cells

Jian-Hua Chen, Axel Ekman, Ralf Bartenschlager, Venera Weinhardt, et.al
Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

Hsin-Fang Chang, Maria Harkiolaki, et.al
The use of soft X-ray tomography to explore mitochondrial structure and function

Valentina Loconte, Kate L.White, et.al
A guide into the world of high-resolution 3D imaging: the case of soft X-ray tomography for the life sciences

Chidinma Adanna Okolo, Diamond Light Source
Soft X-ray tomograms provide a structural basis for whole-cell modeling

Valentina Loconte, Jian-Hua Chen, Bieke Vanslembrouck, Axel A. Ekman, Gerry McDermott, Mark A. Le Gros, Carolyn A. Larabell
Soft X-ray Tomography Reveals HSV-1-Induced Remodeling of Human B Cells

Jian-Hua Chen, Bieke Vanslembrouck , Axel Ekman, Vesa Aho, Carolyn A. Larabell, Mark A. Le Gros, Maija Vihinen-Ranta, Venera Weinhardt
An intensity-based post-processing tool for 3D instance segmentation of organelles in soft X-ray tomograms

Angdi Li, Valentina Loconte, Axel Ekman, Kate White, Raymond C.Stevens, et al
Microscopic Visualization of Cell-Cell Adhesion Complexes at Micro and Nanoscale

Bieke Vanslembrouck, Jian-hua Chen, Carolyn Larabell, Jolanda van Hengel
Advanced Light Source Analytical Techniques for Exploring the Biological Behavior and Fate of Nanomedicines

Mingjing Cao, Kai Zhang, Shuhan Zhang, Yaling Wang, and Chunying Chen
Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection

Kamal L.Nahas, Maria Harkiolaki, Colin M. Crump et.al
Correlative imaging using super-resolution fluorescence microscopy and soft X-ray tomography at cryogenic temperatures provides a new way to assess virosome solutions for vaccine development

Chidinma A.Okolo, Maria Harkiolaki.et.al
A combination of soft X-ray and laser light sources offer 3D high content information on the native state of the cellular environment

Chidinma A Okolo, Thomas M Fish, Kamal L Nahas, Archana C Jadhav, Nina Vyas, Adam Taylor and Maria Harkiolaki
Auto-segmentation and time-dependent systematic analysis of mesoscale cellular structure in β-cells during insulin secretion

Angdi Li, Valentina Loconte, Jitin Singla. et.al.
Cryo soft X-ray tomography to explore Escherichia coli nucleoid remodelling by Hfq master regulator

Antoine Cossa, Eva Pereiro, et.al ALBA Synchroton
Contour, a semi-automated segmentation and quantitation tool for cryo-soft-X-ray tomography

Kamal L Nahas, João Ferreira Fernandes, Colin Crump, Stephen Graham, Maria Harkiolaki
A protocol for full-rotation soft X-ray tomography of single cells

Jian-Hua Chen, Axel Ekman, Ralf Bartenschlager, Venera Weinhardt, et.al
Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

Hsin-Fang Chang, Maria Harkiolaki, et.al
The use of soft X-ray tomography to explore mitochondrial structure and function

Valentina Loconte, Kate L.White, et.al
A guide into the world of high-resolution 3D imaging: the case of soft X-ray tomography for the life sciences

Chidinma Adanna Okolo, Diamond Light Source
Soft X-ray tomograms provide a structural basis for whole-cell modeling

Valentina Loconte, Jian-Hua Chen, Bieke Vanslembrouck, Axel A. Ekman, Gerry McDermott, Mark A. Le Gros, Carolyn A. Larabell
Soft X-ray Tomography Reveals HSV-1-Induced Remodeling of Human B Cells

Jian-Hua Chen, Bieke Vanslembrouck , Axel Ekman, Vesa Aho, Carolyn A. Larabell, Mark A. Le Gros, Maija Vihinen-Ranta, Venera Weinhardt
An intensity-based post-processing tool for 3D instance segmentation of organelles in soft X-ray tomograms

Angdi Li, Valentina Loconte, Axel Ekman, Kate White, Raymond C.Stevens, et al
Microscopic Visualization of Cell-Cell Adhesion Complexes at Micro and Nanoscale

Bieke Vanslembrouck, Jian-hua Chen, Carolyn Larabell, Jolanda van Hengel
Advanced Light Source Analytical Techniques for Exploring the Biological Behavior and Fate of Nanomedicines

Mingjing Cao, Kai Zhang, Shuhan Zhang, Yaling Wang, and Chunying Chen
Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection

Kamal L.Nahas, Maria Harkiolaki, Colin M. Crump et.al
Correlative imaging using super-resolution fluorescence microscopy and soft X-ray tomography at cryogenic temperatures provides a new way to assess virosome solutions for vaccine development

Chidinma A.Okolo, Maria Harkiolaki.et.al
A combination of soft X-ray and laser light sources offer 3D high content information on the native state of the cellular environment

Chidinma A Okolo, Thomas M Fish, Kamal L Nahas, Archana C Jadhav, Nina Vyas, Adam Taylor and Maria Harkiolaki
2021
Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy

Zheng Dang, et al, Hefei Soft-X-ray Beamline, China
Probing the Intracellular Bio-Nano Interface in Different Cell Lines with Gold Nanostars

Cecilia Spedalieri, et al, Department of Chemistry, Humboldt-Universität,
Department X-ray Microscopy, Helmholtz-Zentrum, Berlin
Influence of Nuclear Localization Sequences on the Intracellular Fate of Gold Nanoparticles

Daniela Drescher, et al, Department of Chemistry, Humboldt-Universität, Department of X-Ray Microscopy, Helmholtz-Zen
trum, Berlin
Correlative cryo-imaging of the cellular universe with soft X-rays and laser light used to track F-actin structures in mammalian cells

Mohamed Koronfel, et al, Diamond Light Source, Institute of Molecular and Cell Biology
Using soft X-ray tomography for rapid whole-cell quantitative imaging of SARS-CoV-2-infected cells

Valentina Loconte, Jian-Hua-Chen, et al, Lawrence Berkeley National Laboratory, USA
Imaging of Virus-Infected Cells with Soft X-ray Tomography

Damià Garriga, et al, ALBA Synchrotron Light Source, Centro Nacional de Biotecnología, Spain
Malaria Pigment Crystals, the Achilles Heel of the Malaria Parasite

Sergey Kapishnikov, Weizmann Institute of Science. ChemMedChem
SARS-CoV-2 Assembly and Egress Pathway Revealed by Correlative Multi-modal Multi-scale Cryo-imaging

Luiza Mendonca, Wellcome Trust Centre for Human Genetics, University of Oxford
3D Whole-Cell Mapping of Insulin Secretion

Carolyn Larabell, Advanced Light Source, Berkeley Lab
3D Imaging and Quantification of the Integrin at a Single-Cell Base on a Multisignal Nanoprobe and Synchrotron Radiation Soft X-ray Tomography Microscopy

Chunyu Zhang, et al, Anal.Chem, 2021
Multimodal Imaging and Soft X-Ray Tomography of Fluorescent Nanodiamonds in Cancer Cells

Philipp Reineck, et al, ARC Centre of Excellence for Nanoscale BioPhotonics. Biotechnology Journal 2021
Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells

Alice Dupont Juhl, et al, VILLUM Center for Bioanalytical Sciences, Denmark,
Cryo-Structured Illumination Microscopic Data Collection from Cryogenically Preserved Cells

Nina Vyas, et al, Harwell Science and Innovation Campus, Beamline B24, Diamond Light Source
Compact Cell Imaging Device (CoCID) provides insights into the cellular origins of viral infections

Kenneth Fahy et al 2021 J. Phys. Photonics
Single Cell Cryo-Soft X-Ray Tomography shows that each Chlamydia Trachomatis Inclusion is a unique community of bacteria

Patrick Phillips, et al, Diamond Light Source, Harwell Science and Innovation Campus, UK
Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy

Zheng Dang, et al, Hefei Soft-X-ray Beamline, China
Probing the Intracellular Bio-Nano Interface in Different Cell Lines with Gold Nanostars

Cecilia Spedalieri, et al, Department of Chemistry, Humboldt-Universität,
Department X-ray Microscopy, Helmholtz-Zentrum, Berlin
Influence of Nuclear Localization Sequences on the Intracellular Fate of Gold Nanoparticles

Daniela Drescher, et al, Department of Chemistry, Humboldt-Universität, Department of X-Ray Microscopy, Helmholtz-Zen
trum, Berlin
Correlative cryo-imaging of the cellular universe with soft X-rays and laser light used to track F-actin structures in mammalian cells

Mohamed Koronfel, et al, Diamond Light Source, Institute of Molecular and Cell Biology
Using soft X-ray tomography for rapid whole-cell quantitative imaging of SARS-CoV-2-infected cells

Valentina Loconte, Jian-Hua-Chen, et al, Lawrence Berkeley National Laboratory, USA
Imaging of Virus-Infected Cells with Soft X-ray Tomography

Damià Garriga, et al, ALBA Synchrotron Light Source, Centro Nacional de Biotecnología, Spain
Malaria Pigment Crystals, the Achilles Heel of the Malaria Parasite

Sergey Kapishnikov, Weizmann Institute of Science. ChemMedChem
SARS-CoV-2 Assembly and Egress Pathway Revealed by Correlative Multi-modal Multi-scale Cryo-imaging

Luiza Mendonca, Wellcome Trust Centre for Human Genetics, University of Oxford
3D Whole-Cell Mapping of Insulin Secretion

Carolyn Larabell, Advanced Light Source, Berkeley Lab
3D Imaging and Quantification of the Integrin at a Single-Cell Base on a Multisignal Nanoprobe and Synchrotron Radiation Soft X-ray Tomography Microscopy

Chunyu Zhang, et al, Anal.Chem, 2021
Multimodal Imaging and Soft X-Ray Tomography of Fluorescent Nanodiamonds in Cancer Cells

Philipp Reineck, et al, ARC Centre of Excellence for Nanoscale BioPhotonics. Biotechnology Journal 2021
Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells

Alice Dupont Juhl, et al, VILLUM Center for Bioanalytical Sciences, Denmark,
Cryo-Structured Illumination Microscopic Data Collection from Cryogenically Preserved Cells

Nina Vyas, et al, Harwell Science and Innovation Campus, Beamline B24, Diamond Light Source
Compact Cell Imaging Device (CoCID) provides insights into the cellular origins of viral infections

Kenneth Fahy et al 2021 J. Phys. Photonics
Single Cell Cryo-Soft X-Ray Tomography shows that each Chlamydia Trachomatis Inclusion is a unique community of bacteria

Patrick Phillips, et al, Diamond Light Source, Harwell Science and Innovation Campus, UK
2020
Quantitative three‐dimensional nondestructive imaging of whole anaerobic ammonium‐oxidizing bacteria

M-W Peng, Chongqing University, China. Journal of Synchrotron Radiation
Synchrotron multimodal imaging in a whole cell reveals lipid droplet core organization

Frederic Jamme, Synchrotron SOLEIL, France. Journal of Synchrotron Radiation
3D Correlative Cryo-Structured Illumination Fluorescence and Soft X-ray Microscopy Elucidates Reovirus Intracellular Release Pathway

Ilias Kounatidis, Diamond Light Source, UK. PubMed.gov
X‑ray tomography of cryopreserved human prostate cancer cells: mitochondrial targeting by an organoiridium photosensitiser

E. M. Bolitho, University of Warwick, UK. Journal of Biological Inorganic Chemistry
Cells Undergo Major Changes in the Quantity of Cytoplasmic Organelles after Uptake of Gold Nanoparticles with Biologically Relevant Surface Coatings

Burcu Kepsutlu, Helmholtz Zentrum Berlin für Materialien und Energie GmbH, Germany
Strong intracellular signal inactivation produces sharper and more robust signaling from cell membrane to nucleus

Jingwei Ma, Department of Mathematics and Statistics, Boston University
Quantitative three‐dimensional nondestructive imaging of whole anaerobic ammonium‐oxidizing bacteria

M-W Peng, Chongqing University, China. Journal of Synchrotron Radiation
Synchrotron multimodal imaging in a whole cell reveals lipid droplet core organization

Frederic Jamme, Synchrotron SOLEIL, France. Journal of Synchrotron Radiation
3D Correlative Cryo-Structured Illumination Fluorescence and Soft X-ray Microscopy Elucidates Reovirus Intracellular Release Pathway

Ilias Kounatidis, Diamond Light Source, UK. PubMed.gov
X‑ray tomography of cryopreserved human prostate cancer cells: mitochondrial targeting by an organoiridium photosensitiser

E. M. Bolitho, University of Warwick, UK. Journal of Biological Inorganic Chemistry
Cells Undergo Major Changes in the Quantity of Cytoplasmic Organelles after Uptake of Gold Nanoparticles with Biologically Relevant Surface Coatings

Burcu Kepsutlu, Helmholtz Zentrum Berlin für Materialien und Energie GmbH, Germany
Strong intracellular signal inactivation produces sharper and more robust signaling from cell membrane to nucleus

Jingwei Ma, Department of Mathematics and Statistics, Boston University
2019
Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo

Sergey Kapishnikov, Niels Bohr Institute, Copenhagen. PNAS
Soft X-Ray Microscopy of Complex Samples – from Tissue Culture to Tissue Components

Casper Hempel, Technical University of Denmark. Wiley Analytical Science
3D Quantitative and Ultrastructural Analysis of Mitochondria in a Model of Doxorubicin Sensitive and Resistant Human Colon Carcinoma Cells

Claudia Moscheni, Universita degli Studi di Milano. OubMed.gov
Correlative cryo-soft X-ray tomography of cells

Eva Pereiro, ALBA Synchhrotron, Barcelona. Springer Biophysical Reviews
Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo

Sergey Kapishnikov, Niels Bohr Institute, Copenhagen. PNAS
Soft X-Ray Microscopy of Complex Samples – from Tissue Culture to Tissue Components

Casper Hempel, Technical University of Denmark. Wiley Analytical Science
3D Quantitative and Ultrastructural Analysis of Mitochondria in a Model of Doxorubicin Sensitive and Resistant Human Colon Carcinoma Cells

Claudia Moscheni, Universita degli Studi di Milano. OubMed.gov
Correlative cryo-soft X-ray tomography of cells

Eva Pereiro, ALBA Synchhrotron, Barcelona. Springer Biophysical Reviews
2018
Expanding horizons of cryo-tomography to larger volumes

Michael Elbaum, ScienceDirect
Analysis of cholesterol export from endo-lysosomes by Niemann Pick C2 protein using combined fluorescence and X-ray microscopy

Alice Dupont, Villum Center for Biological Sciences, Denmark
Native-state imaging of calcifying and noncalcifying microalgae reveals similarities in their calcium storage organelles

Matthew C. Spink, Diamond Light Source, et al.
Microscience & Microanalysis
Cryo-soft X-ray tomography: using soft X-rays to explore the ultrastructure of whole cells

Maria Harkiolaki, Diamond Light Source, UK. et al.
Emerging Topics in Life Science
Integration of Soft X-ray Tomography and High Resolution Fluorescence Microscopy

Zi-Jing Lin, National Synchrotron Radiation Research Center, Taiwan
Microscience & Microanalysis
Correlation of Cryo Soft X-ray Tomography with Cryo Fluorescence Microscopy to Characterise Cellular Organelles at Beamline B24, Diamond Light Source

Matthew C. Spink, Diamond Light Source, et al.
Microscience & Microanalysis
PSF correction in soft x-ray tomography

Axel Ekmana, Venera Weinhardt, Dept of Anatomy, UCSF
Journal of Structural Biology
Expanding horizons of cryo-tomography to larger volumes

Michael Elbaum, ScienceDirect
Analysis of cholesterol export from endo-lysosomes by Niemann Pick C2 protein using combined fluorescence and X-ray microscopy

Alice Dupont, Villum Center for Biological Sciences, Denmark
Native-state imaging of calcifying and noncalcifying microalgae reveals similarities in their calcium storage organelles

Matthew C. Spink, Diamond Light Source, et al.
Microscience & Microanalysis
Cryo-soft X-ray tomography: using soft X-rays to explore the ultrastructure of whole cells

Maria Harkiolaki, Diamond Light Source, UK. et al.
Emerging Topics in Life Science
Integration of Soft X-ray Tomography and High Resolution Fluorescence Microscopy

Zi-Jing Lin, National Synchrotron Radiation Research Center, Taiwan
Microscience & Microanalysis
Correlation of Cryo Soft X-ray Tomography with Cryo Fluorescence Microscopy to Characterise Cellular Organelles at Beamline B24, Diamond Light Source

Matthew C. Spink, Diamond Light Source, et al.
Microscience & Microanalysis
PSF correction in soft x-ray tomography

Axel Ekmana, Venera Weinhardt, Dept of Anatomy, UCSF
Journal of Structural Biology
2017
Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells

Fernando Ugarte et al, Stem Cell Reports
Biochemistry of malaria parasite infected red blood cells by X-ray microscopy

S. Kapishnikov et al, Nature
3D membrane segmentation and quantification of intact thick cells using cryo soft X-ray transmission microscopy: A pilot study

Ruben Cardenes et al, PLOS ONE
Mycobacterium tuberculosis replicates within necrotic human macrophages

Thomas L. Lerner et al, Journal of Cell Biology
Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

Tohru Takaki et al, Nature Communications
Mitosis can drive cell cannibalism through entosis

Joanne Durgan et al, eLIFE
Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells

Fernando Ugarte et al, Stem Cell Reports
Biochemistry of malaria parasite infected red blood cells by X-ray microscopy

S. Kapishnikov et al, Nature
3D membrane segmentation and quantification of intact thick cells using cryo soft X-ray transmission microscopy: A pilot study

Ruben Cardenes et al, PLOS ONE
Mycobacterium tuberculosis replicates within necrotic human macrophages

Thomas L. Lerner et al, Journal of Cell Biology
Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

Tohru Takaki et al, Nature Communications
Mitosis can drive cell cannibalism through entosis

Joanne Durgan et al, eLIFE
2016
Soft X-ray Tomography Reveals Gradual Chromatin Compaction and Reorganization during Neurogenesis in Vivo.

Mark A. Le Gros et al, Cell Reports
Cryo‑soft X‑ray tomography as a quantitative three‑dimensional tool to model nanoparticle:cell interaction

Michele Chiappi et al, Journal of Nanobiotechnology
Herpes simplex virus 1 induces egress channels through marginalized host chromatin

Markko Myllys et al, Nature / Scientific Reports
Structural Changes In Cells Imaged by Soft X‑ray Cryo-Tomography During Hepatitis C Virus Infection

Ana J. Perez-Berna et al, ACS Nano
Resolving new ultrastructural features of cytokinetic abscission with soft-X-ray cryo-tomography

Shachar Sherman et al, Nature / Scientific Reports
Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography

Michele C. Darrow, Journal of Cell Science
Putting molecules in their place

Bertrand P. Cinquin, Journal of Cellular Biochemistry
Development of Correlative Cryo-soft X‑ray Tomography and Stochastic Reconstruction Microscopy. A Study of Cholesterol Crystal Early Formation in Cells

Neta Varsano, Journal of the Americal Chemical Society
Correlative cryo-fluorescence and cryo-soft X-ray tomography of adherent cells at European synchrotrons

R. Carzaniga et al, Methods in Cell Biology
Analysis of ER–mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells

Kristin Elgass et al, Journal of Cell Science
The yeast polo kinase, Cdc5, regulates the shape of the mitotic nucleus

Alison D. Walters et al, Current Biology
A 3D cellular context for the macromolecular world

Ardan Patwardhan et al, Nature Structural & Molecular Biology
Quantitatively Imaging Chromosomes by Correlated Cryo-Fluorescence and Soft X-Ray Tomographies

Elizabeth A Smith et al, Biophysical Journal
Imaging endosomes and autophagosomes in whole mammalian cells using correlativecryo-fluorescenceandcryo-softX-raymicroscopy (cryo-CLXM)

Elizabeth Duke et al, Ultramicroscopy
Three-dimensional imaging of human stem cells using soft X-ray tomography

J.C. Niclis et al, Nature Methods
Imaging Drosophila brain by combining cryo-soft X-ray microscopy of thick vitreous sections and cryo-electron microscopy of ultrathin vitreous sections

Amélie Leforestier et al, Journal of Structural Biology
Visualizing Cell Architecture and Molecular Location Using Soft X-Ray Tomography and Correlated Cryo-Light Microscopy

Gerry McDermott et al, Annual Reviews of Physical Chemistry
Soft X-ray Tomography Reveals Gradual Chromatin Compaction and Reorganization during Neurogenesis in Vivo.

Mark A. Le Gros et al, Cell Reports
Cryo‑soft X‑ray tomography as a quantitative three‑dimensional tool to model nanoparticle:cell interaction

Michele Chiappi et al, Journal of Nanobiotechnology
Herpes simplex virus 1 induces egress channels through marginalized host chromatin

Markko Myllys et al, Nature / Scientific Reports
Structural Changes In Cells Imaged by Soft X‑ray Cryo-Tomography During Hepatitis C Virus Infection

Ana J. Perez-Berna et al, ACS Nano
Resolving new ultrastructural features of cytokinetic abscission with soft-X-ray cryo-tomography

Shachar Sherman et al, Nature / Scientific Reports
Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography

Michele C. Darrow, Journal of Cell Science
Putting molecules in their place

Bertrand P. Cinquin, Journal of Cellular Biochemistry
Development of Correlative Cryo-soft X‑ray Tomography and Stochastic Reconstruction Microscopy. A Study of Cholesterol Crystal Early Formation in Cells

Neta Varsano, Journal of the Americal Chemical Society
Correlative cryo-fluorescence and cryo-soft X-ray tomography of adherent cells at European synchrotrons

R. Carzaniga et al, Methods in Cell Biology
Analysis of ER–mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells

Kristin Elgass et al, Journal of Cell Science
The yeast polo kinase, Cdc5, regulates the shape of the mitotic nucleus

Alison D. Walters et al, Current Biology
A 3D cellular context for the macromolecular world

Ardan Patwardhan et al, Nature Structural & Molecular Biology
Quantitatively Imaging Chromosomes by Correlated Cryo-Fluorescence and Soft X-Ray Tomographies

Elizabeth A Smith et al, Biophysical Journal
Imaging endosomes and autophagosomes in whole mammalian cells using correlativecryo-fluorescenceandcryo-softX-raymicroscopy (cryo-CLXM)

Elizabeth Duke et al, Ultramicroscopy
Three-dimensional imaging of human stem cells using soft X-ray tomography

J.C. Niclis et al, Nature Methods
Imaging Drosophila brain by combining cryo-soft X-ray microscopy of thick vitreous sections and cryo-electron microscopy of ultrathin vitreous sections

Amélie Leforestier et al, Journal of Structural Biology
Visualizing Cell Architecture and Molecular Location Using Soft X-Ray Tomography and Correlated Cryo-Light Microscopy

Gerry McDermott et al, Annual Reviews of Physical Chemistry
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