Product

We've developed a high throughput, bench-top, Soft X-Ray Microscope - The SXT100

The  SXT100  is the only commercial, lab-based solution for imaging subcellular structure.

No other high resolution imaging modality is capable of quantitatively imaging the subcellular organization of whole hydrated cells, up to 15μm thick at resolutions up to 40 nm, in their native state, with very little preparation and without the use of stains or other contrast enhancing agents.

The key technology at the core of the SXT100 is a high-performance soft x-ray light source based on laser-produced plasma emission. The tiny fireball produced emits the soft x-rays that are used for cell imaging but it also produces a lot of metal debris. Patented, self-healing optics are then employed to collect, filter and focus the soft x-rays onto the cell sample to be imaged.


This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 738774.

Soft X-Ray Microscope

The ability to image an entire cell in 3D enables detection of rare events within the cell. This property is extremely important and makes X-ray microscopy unique. For example, in drug delivery studies it reveals key sub-cellular changes which can easily be missed by conventional electron microscopy where only a few sections from the entire cell are actually examined.   
 
Dr. James McNally, Senior Synchrotron Scientist, Helmholtz Zentrum Berlin.

Filling the imaging gap for a whole-cell nanotomography microscope

Soft X-ray Tomography (SXT) perfectly fits the gap in the market between the imaging capabilities of light and electron microscopy where cell biologists are seeking to image the whole internal structure of intact biological cells at the nanoscale. This imaging modality is very complementary to both light and electron microscopy, which can be correlated with soft x-ray microscopy to extend and enhance the benefits of these mature imaging modalities.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 738774.