This August, Wisconsin will become the global centre of the microscopy community as it hosts two of the world’s premier international microscopy conferences in consecutive weeks. SiriusXT is delighted to announce that it will be participating in both events, highlighting the growing role of laboratory-based Soft X-ray Tomography (SXT) in correlative imaging and structural biology.

The first event, Microscopy & Microanalysis (M&M) 2026, takes place in Milwaukee from August 2–6. M&M is one of the largest and most influential microscopy conferences in the world, bringing together thousands of researchers, instrument developers and industry leaders spanning the life and physical sciences. The conference provides a unique forum for showcasing the latest advances in microscopy technologies, imaging workflows and scientific discovery. 

Just days later, the focus shifts to Madison, where the 11th International Congress on Electron Tomography (ICET 2026) will be held from August 9–12. Taking place every four years, ICET is the leading international meeting dedicated to electron tomography and cryo-electron tomography (cryo-ET), bringing together many of the world’s foremost experts in three-dimensional structural biology, instrumentation and computational imaging. 

Together, these conferences reflect an important trend in biological imaging. While cryo-electron tomography continues to reveal biological structures at unprecedented molecular resolution, there is increasing recognition that understanding biological function also requires imaging technologies capable of providing the larger cellular and tissue context in which those molecular processes occur.

This growing emphasis on “imaging across scales” is creating new opportunities for correlative imaging workflows that combine complementary techniques rather than relying on a single imaging modality.

SiriusXT’s SXT-100 laboratory Soft X-ray Tomography microscope has been developed specifically to address this challenge. By providing native-contrast, three-dimensional imaging of intact cryogenically preserved cells at approximately 50 nm isotropic resolution, the SXT-100 complements fluorescence microscopy and cryo-electron microscopy, providing the three-dimensional volume context needed to interpret molecular-resolution cryo-ET data within the architecture of intact cells.

Throughout both conferences, SiriusXT will demonstrate how Soft X-ray Tomography is helping researchers:

• Generate the whole-cell volume context needed to interpret cryo-electron tomography data. 
• Identify rare biological events and target regions of interest for cryo-FIB milling and cryo-ET. 
• Correlate fluorescence, X-ray and electron microscopy within integrated imaging workflows. 
• Bridge the gap between whole-cell biology and molecular structural biology. 

At M&M 2026, SiriusXT will exhibit the SXT-100 at Booth 230 and present one invited platform lecture together with four scientific posters covering applications in disease research, correlative imaging, nanoparticle localisation and whole-cell cryogenic imaging.

The following week at ICET 2026, SiriusXT will present a scientific poster describing how Correlative Light, Electron and X-ray Microscopy (CLEXM) workflows enable researchers to bridge scales—from intact cells and tissues to molecular-resolution cryo-electron tomography.

“These two conferences provide an ideal opportunity to engage with the international microscopy community,” said Tony McEnroe, Managing Director of SiriusXT. “Increasingly, researchers are looking beyond individual imaging technologies and towards integrated workflows that connect molecular structure with biological context. We believe Soft X-ray Tomography has an important role to play in enabling that vision.”

With two major international conferences taking place back-to-back, August promises to be an exciting month for microscopy. SiriusXT looks forward to meeting researchers, collaborators and partners from around the world to discuss how laboratory-based Soft X-ray Tomography is helping advance the next generation of correlative imaging workflows.