On 27th January 2023, Kenneth Fahy (VP of Product Management, SiriusXT) spoke in the latest episode of the Euro-BioImaging Tech Exchange webinar series. This was a fantastic opportunity to present our innovative lab-scale soft X-ray microscope (the “SXT-100”) to the Euro-Bioimaging network.
Euro-BioImaging Virtual Pub, Tech Exchange webinar series provides an opportunity for imaging facilities and users in the Euro-BioImaging network to learn about new technologies and imaging products and exchange technical questions.
In this talk “Seeing Cells in 3D: Bringing Soft X-ray Tomography to the Lab” SiriusXT presented an overview of the SXT-100 including some recent imaging data from ongoing scientific case studies which highlight the potential of cryo-soft X-ray microscopy in the bioimaging field. Analysis of three-dimensional biological cell samples is critical for understanding the mechanisms of viral disease and for developing novel therapeutics. Soft X-ray microscopy (SXM) is a one-of-a-kind method that can image complete intact cells in 3D under normal and infected conditions, with high throughput and spatial resolution, without labelling or fixation. The main challenge of SXM is that the photonic illumination required for imaging has heretofore only been available at synchrotron labs.
SiriusXT has developed a lab-scale SXM for three-dimensional imaging of whole cells and tissue sections that can be performed in a laboratory. The capabilities of this compact imaging device, combined with complementary light and electron microscopy approaches, are currently being demonstrated through a series of virology use cases to generate new scientific knowledge on the viral life cycle and host cell response to viral infection.