Pioneering Drug Research
SiriusXT is a valuable partner for pharmaceutical researchers and biotech companies working on drug discovery and development. The SXT-100 allows scientists to visualise protein-drug interactions and track drug delivery mechanisms inside cells in real time.
Imaging Cellular Response to Treatment
Soft X-ray tomography can be applied to test how drugs affect cellular structures in disease models. It allows researchers to observe how treatments interact with cells, how they alter the cell morphology, or if they induce any toxic effects on tissues. It is also valuable in screening new chemicals and pharmaceuticals for potential toxic effects by assessing changes in cellular architecture that may not be visible with conventional imaging techniques.
Unveiling the Inner Workings of Drug-Cell Interactions
Soft X-ray microscopy can be used to observe how drugs interact with cells at the molecular and cellular levels. Researchers can:
Track intracellular nanoparticle delivery and cargo localisation
Track the journey of therapeutic nanoparticles from cellular uptake to endosomal escape and cargo release—crucial for validating delivery mechanisms in nanomedicine and vaccine development.
Monitor structural changes in response to drug treatment
Monitor drug-induced organelle remodelling (e.g. mitochondrial swelling, ER fragmentation) over time to assess mechanism of action, toxicity, or resistance.
Observe rare or heterogeneous cellular responses
Observe low-frequency events like autophagosome formation, mitotic errors, or vesicle fusion that indicate a drug’s off-target effects or stress induction.
Visualise 3D organelle architecture in complex environments
Visualise full-cell organelle morphology and spatial distribution in patient-derived organoids or co-culture systems, offering insight into how drugs act in a realistic biological context.
Preclinical Drug Assessment
The SXT-100 enables high-resolution, 3D imaging of intact cells to assess drug-induced structural changes, organelle remodelling, and intracellular delivery in native conditions—providing early, label-free insight into efficacy, toxicity, and mechanism of action during preclinical drug development.
Nanoparticle Delivery Monitoring
SXT enables 3D, label-free visualisation of nanoparticle uptake, trafficking, and cargo release in intact cells. Combined with correlative imaging, it helps study endosomal escape mechanisms and assess how surface functionalisation affects NP uptake—supporting optimisation of delivery strategies and cargo off-loading at targeted cellular endpoints in nanomedicine development.
Let’s Connect
Accelerate Discovery with SiriusXT’s Advanced Imaging
Encourage researchers to contact SiriusXT and explore how the SXT-100 can enhance their disease research.
