About

We’ve developed a high throughput, bench-top, Soft X-Ray Microscope - The SXT100

The SXT100 is the only high throughput lab-based solution for imaging subcellular structure. No other high resolution imaging modality is capable of quantitatively imaging the subcellular organization of whole hydrated cells, up to 15μm thick at resolutions up to 40 nm, in their native state, with very little preparation and without the use of stains or other contrast enhancing agents.


Company History

The company spun out of the UCD School of Physics Spectroscopy Group in 2015 and is based in Dublin, Ireland. The vacuum-based laser-produced plasma technology, which is the core technology that underpins the SXT100, has been developed at UCD since 2005 by a team of internationally-renowned plasma physicists.

Ref: 3D image of the inactive X chromosome. Image courtesy of Prof. Carolyn Larabell of the NCXT, Berkeley and published in Biophysical J., Oct 2014, Vol 107, pgs. 1988-1996. Ref: 3D images of yeast cells at the four main stages of the cell cycle. Image courtesy of Prof. Carolyn Larabell of the NCXT, Berkeley and published in Yeast 2011; 28: 227–236.

Synchrotrons

Up to now, the only sources of soft x-rays bright enough to illuminate a soft x-ray microscope are produced by synchrotrons. These large, football stadium sized facilities accelerate electrons in a circular path to very high energies. When these electrons change direction they lose energy in the form of soft x-rays, which are directed via a beamline to the soft x-ray microscope. Only four synchrotrons with soft x-ray beamlines and microscopes capable of biological imaging exist.

Technology Innovation

The key technology at the core of the SXT100 is a high-performance soft x-ray light source based on laser-produced plasma emission. The tiny fireball produced emits the soft x-rays that are used for cell imaging but it also produces a lot of metal debris. Patented, self-healing optics are then employed to collect, filter and focus the soft x-rays onto the cell sample to be imaged.

About

We’ve developed a high throughput, bench-top, Soft X-Ray Microscope - The SXT100

The SXT100 is the only high throughput lab-based solution for imaging subcellular structure. No other high resolution imaging modality is capable of quantitatively imaging the subcellular organization of whole hydrated cells, up to 15μm thick at resolutions up to 40 nm, in their native state, with very little preparation and without the use of stains or other contrast enhancing agents.


Company History

The company spun out of the UCD School of Physics Spectroscopy Group in 2015 and is based in Dublin, Ireland. The vacuum-based laser-produced plasma technology, which is the core technology that underpins the SXT100, has been developed at UCD since 2005 by a team of internationally-renowned plasma physicists.

Product

The SXT100 will generate high-throughput, on-demand, 3-D images of whole cells in a near-native, hydrated state.

• System throughput: 50+ tomographs/day
• Spatial Resolution: sub-40nm
• System Footprint: 3m²

Ref: This figure shows hematopoiesis (blood cell development). The cells are from mouse bone marrow. Image courtesy of Prof. Carolyn Larabell of the NCXT, Berkeley and published in Stem Cell Reports, Nov 10, 2015, Vol 5, pgs. 1-13.

Applications

Disease Research Disease Research
Drug Discovery Drug Discovery
Bio Engineering Bio Engineering
Food Science Food Science
Clinical Diagnostics Clinical Diagnostics
Cosmetics Cosmetics
Materials Science Materials Science

-many more

Potential Applications

Interested?

Get in Touch

Email Us